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Protective Effect of S-adenosyl-L-methionine Against CCl4-induced Hepatotoxicity in Cultured Hepatocytes

Protective Effect of S-adenosyl-L-methionine Against CCl4-induced Hepatotoxicity in Cultured Hepatocytes

M Tsuji, K Kodama, K Oguchi

Jpn J Pharmacol. 1990 Feb;52(2):209-14.

PMID: 2313931

Abstract:

Effect of S-adenosyl-L-methionine disulfate tosylate salt (SAMe-ST) and L-methionine (L-Met) on primary cultured rat hepatocytes were studied. In cultured hepatocytes treated with CCl4, SAMe-ST and L-Met suppressed the decrease in urea-nitrogen secretion as well as the leakages of GOT and GPT. The membrane-protective action of these two compounds was verified by the histological data. Failure of SAMe-ST to counteract CCl4-induced reduction of radioactive leucine incorporation into the trichloroacetic acid-insoluble materials in hepatocytes indicates that the observed effects of SAMe-ST or L-Met do not involve acceleration of protein synthesis. The present results indicate that SAMe-ST remarkably protects hepatocytes from CCl4-induced hepatotoxicity, probably by either changing the structure or compositions of membrane phospholipids or by modifying the interaction of CCl4 with the intracellular drug-metabolizing enzyme systems.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP97540222	Ademetionine disulfate tosylate		97540-22-2	Price

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