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Protective Effects of Chlorogenic Acid in 3-nitropropionic Acid Induced Toxicity and Genotoxicity

Protective Effects of Chlorogenic Acid in 3-nitropropionic Acid Induced Toxicity and Genotoxicity

Norberto Alarcón-Herrera, Saúl Flores-Maya, Belén Bellido, Ana M García-Bores, Ernesto Mendoza, Guillermo Ávila-Acevedo, Elizabeth Hernández-Echeagaray

Food Chem Toxicol. 2017 Nov;109(Pt 2):1018-1025.

PMID: 28478101

Abstract:

Mitochondrial inhibition with the toxin 3-Nitropropionic acid (3-NP) has been used to study the underlying mechanisms in striatal neurodegeneration, but few experiments have evaluated its toxicity and genotoxicity of in vivo administration. Furthermore, different antioxidant molecules may prevent degeneration induced by the toxic effects of 3-NP. Therefore, the purpose of this study was to evaluate the toxicity and genotoxicity induced by 3-NP (15 mg/kg) in the micronuclei assay method; also, we assessed chlorogenic acid (CGA, 100 mg/kg) for its anti-toxic and anti-genotoxic effect in damage produced by in vivo treatment with 3-NP. 3-NP induced toxicity and genotoxicity. CGA administered as a co-treatment with 3-NP (3-NP + CA) reduced toxicity by 32.76%, as a pre-treatment for 5 days only, followed by 3-NP treatment (P/CA, 3-NP) inhibiting toxicity by 24.04%, or as a pre-treatment, plus a co-treatment with 3-NP (P/CA, 3-NP + CA) avoided any toxic effect. CGA alone did not exhibit any toxic effect. Only P/CGA, 3-NP + CGA group, avoided toxicity and genotoxicity, suggesting that CGA could be suitable to prevent, reduce or delay toxicity and cell death.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP504881-A	3-Nitropropionic acid		504-88-1	Price

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