Home
Resources
Publications
Protective Efficacy of IgA Monoclonal Antibodies to O and H Antigens in a Mouse Model of Intranasal Challenge With Salmonella Enterica Serotype Enteritidis

Protective Efficacy of IgA Monoclonal Antibodies to O and H Antigens in a Mouse Model of Intranasal Challenge With Salmonella Enterica Serotype Enteritidis

Ianko D Iankov, Dragomir P Petrov, Ivan V Mladenov, Iana H Haralambieva, Ognian K Kalev, Maria S Balabanova, Ivan G Mitov

Microbes Infect. 2004 Aug;6(10):901-10.

PMID: 15310466

Abstract:

Protective properties of immunoglobulin A (IgA) monoclonal antibodies (MAbs) directed against O and H antigens of Salmonella enterica serotype Enteritidis (S. enteritidis) were evaluated in a model of generalized infection after intranasal (i.n.) inoculation of BALB/c mice. Passive i.n. instillation of antibodies 1 h before i.n. challenge did not prevent infection, and mice developed rapid inflammatory response in the lower respiratory tract. The passive systemic immunization was partially protective and a single intravenous (i.v.) injection of both O and H antigen specific IgA antibodies prolonged survival period of the infected animals. Permanent secretion of O:9 specific IgA MAb 177E6 into the respiratory tract in a "backpack" tumor model protected 50% of animals infected i.n. with a high dose of virulent S. enteritidis strain. Thus, secretory IgA (S-IgA) directed against O:9 antigen alone can prevent bacterial invasion in the respiratory epithelium.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS741386	Lipopolysaccharides from Salmonella enterica serotype enteritidis			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: