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Protein Adsorption, Fibroblast Activity and Antibacterial Properties of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric Acid) Grafted With Chitosan and Chitooligosaccharide After Immobilized With Hyaluronic Acid

Protein Adsorption, Fibroblast Activity and Antibacterial Properties of poly(3-hydroxybutyric acid-co-3-hydroxyvaleric Acid) Grafted With Chitosan and Chitooligosaccharide After Immobilized With Hyaluronic Acid

S-G Hu, C-H Jou, M C Yang

Biomaterials. 2003 Jul;24(16):2685-93.

PMID: 12711514

Abstract:

Poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid) (PHBV) membrane was treated with ozone and grafted with acrylic acid. The resulting membranes were further grafted with chitosan (CS) or chitooligosaccharide (COS) via esterification. Afterward hyaluronic acid (HA) was immobilized onto CS- or COS-grafting membranes. The antibacterial activity of CS and COS against Staphylococus aureus, Escherichia coli, and Pseudomonas aeruginosa was preserved after HA immobilization. Among them, CS-grafted PHBV membrane showed higher antibacterial activity than COS-grafted PHBV membrane. In addition, after CS- or COS-grafting, the L929 fibroblasts attachment and protein adsorption were improved, while the cell number was decrease. After immobilizing HA, the cell proliferation was promoted, the protein adsorption was decreased, and the cell attachment was slightly lower than CS- or COS-grafting PHBV.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP80181313	Poly(3-hydroxybutyric acid-co-3-hydroxyvaleric acid)		80181-31-3	Price

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