Home
Resources
Publications
Protein Detection and Quantitation by Tetraphenylethene-Based Fluorescent Probes With Aggregation-Induced Emission Characteristics

Protein Detection and Quantitation by Tetraphenylethene-Based Fluorescent Probes With Aggregation-Induced Emission Characteristics

Hui Tong, Yuning Hong, Yongqiang Dong, Matthias Häussler, Zhen Li, Jacky W Y Lam, Yuping Dong, Herman H-Y Sung, Ian D Williams, Ben Zhong Tang

J Phys Chem B. 2007 Oct 11;111(40):11817-23.

PMID: 17877385

Abstract:

Three functionalized derivatives of tetraphenylethylene (TPE), namely, 1,2-bis(4-methoxyphenyl)-1,2-diphenylethene (1), 1,2-bis(4-hydroxyphenyl)-1,2-diphenylethene (2), and 1,2-bis[4-(3-sulfonatopropoxyl)phenyl]-1,2-diphenylethene sodium salt (3), were synthesized and their fluorescence properties were investigated. All the TPE molecules are nonluminescent in the solution state but are induced to emit efficiently by aggregate formation. This novel process of aggregation-induced emission (AIE) is rationalized to be caused by the restriction of intramolecular rotations of the dye molecules in the aggregate state. The possibility of utilizing the AIE effect for protein detection and quantification is explored using bovine serum albumin (BSA) as a model protein, with salt 3 being found to perform as a stable, sensitive, and selective bioprobe.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP68578789	1,2-Bis(4-methoxyphenyl)-1,2-diphenylethene		68578-78-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: