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Protein Disulfide Isomerases as Potential Therapeutic Targets for Influenza A and B Viruses

Protein Disulfide Isomerases as Potential Therapeutic Targets for Influenza A and B Viruses

Yunjeong Kim, Kyeong-Ok Chang

Virus Res. 2018 Mar 2;247:26-33.

PMID: 29382552

Abstract:

Seasonal flu as well as potential pandemic flu outbreaks continuously underscores the importance of the preventive and therapeutic measures against influenza viruses. During screening of natural and synthetic small molecules against influenza A and B virus, we identified juniferdin as a highly effective inhibitor against both viruses in cells. Since juniferdin is known to inhibit protein disulfide isomerases (PDIs), multiple PDI inhibitors were tested against these viruses. Among PDI inhibitors, 16F16, PACMA31, isoquercetin, epigallocatechin-3-gallate or nitazoxanide significantly reduced the replication of influenza A and B viruses in MDCK and A549 cells. Furthermore, siRNAs specific to three PDI family members (PDI1, PDIA3 or PDIA4) also significantly reduced the replication of influenza A and B viruses in cells. These results suggest that PDIs may serve as excellent targets for the development of new anti-influenza drugs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP922507800	PDI inhibitor 16F16		922507-80-0	Price

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