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Protein-resistant Polymer Coatings Based on Surface-Adsorbed Poly(aminoethyl methacrylate)/poly(ethylene Glycol) Copolymers

Protein-resistant Polymer Coatings Based on Surface-Adsorbed Poly(aminoethyl methacrylate)/poly(ethylene Glycol) Copolymers

Leonid Ionov, Alla Synytska, Elisabeth Kaul, Stefan Diez

Biomacromolecules. 2010 Jan 11;11(1):233-7.

PMID: 20000461

Abstract:

We report on the protein-resistant properties of glass substrates coated with novel copolymers of 2-aminoethyl methacrylate hydrochloride and poly(ethylene glycol) methyl ether methacrylate (AEM-PEG). In comparison to currently available protein-blocking polymer systems, such as poly-l-lysine-poly(ethylene glycol), silane-based poly(ethylene glycol), and poly(ethylene glycol) brushes prepared by surface-initiated polymerization, the proposed AEM-PEG offers the combined advantages of low cost, simplicity of use, and applicability in aqueous solutions. We demonstrate the capability of AEM-PEG to block the surface binding of globular proteins (tubulin), their assemblies (microtubules), and functional motor proteins (kinesin-1). Moreover, we demonstrate the applicability of AEM-PEG for surface patterning of proteins in microfluidic devices.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP26915720	Poly(ethylene glycol) methyl ether methacrylate		26915-72-0	Price

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