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Proteinase 3 Phosphonic Inhibitors

Proteinase 3 Phosphonic Inhibitors

Renata Grzywa, Adam Lesner, Brice Korkmaz, Marcin Sieńczyk

Biochimie. 2019 Nov;166:142-149.

PMID: 30876969

Abstract:

Neutrophils are one of the most important military services of the armed forces of the immune system, a crucial line of defense against bacterial or fungal onslaughts. One of their mechanisms of action relies on the production of serine proteases. One of these enzymes is proteinase 3 (PR3), which is engaged in the processing of pro-inflammatory cytokines, receptors, heat shock proteins and in the generation of antibacterial peptides. Despite its protective function, uncontrolled activity of PR3 has been associated with the progression of inflammation and tissue injury. Although PR3 was characterized at the beginning of 90's of the last century for the first time, the research on the development of its inhibitors is barely noticeable. Here we present the recent findings on the design, synthesis and the activity of phosphonic PR3 inhibitors together with the historical perspective.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42418006	Proteinase 3 from human leukocytes			Price

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