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Protoporphyrin IX Fluorescence as Potential Indicator of Psoriasis Severity and Progression

Protoporphyrin IX Fluorescence as Potential Indicator of Psoriasis Severity and Progression

Bo Wang, Yu-Ting Xu, Li Zhang, Jie Zheng, Ronald Sroka, Hong-Wei Wang, Xiu-Li Wang

Photodiagnosis Photodyn Ther. 2017 Sep;19:304-307.

PMID: 28625924

Abstract:

Background and objectives:
In psoriatic lesions, fluorescence diagnosis with blue light can detect protoporphyrin IX accumulation, especially after topical 5-aminolaevulinic acid (ALA) application. However, variable fluorescence distributions, interpersonal variations and long incubation time limit its wide application in clinic. This study is aimed to identify a consistent and convenient method to facilitate diagnosis and evaluation of psoriatic lesions.
Methods:
104 psoriatic lesions from 30 patients were evaluated. Single lesion PSI scoring and fluorescence by macrospectrofluorometry were recorded on each lesion before and after treatment with narrow-band UVB.
Results:
Punctate red fluorescence, emitted mainly by protoporphyrin IX, is observed in some psoriatic lesions. According to psoriasis severity index, fluorescence-positive lesions are more severe than lesions without fluorescence. We found a significant positive correlation between psoriasis severity and fluorescence intensity from protoporphyrin IX.
Conclusions:
Protoporphyrin IX-induced red fluorescence can be used as a novel and convenient approach for psoriasis diagnosis and progression evaluation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP553128	Protoporphyrin IX		553-12-8	Price

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