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Pterosin B Prevents Chondrocyte Hypertrophy and Osteoarthritis in Mice by Inhibiting Sik3

Pterosin B Prevents Chondrocyte Hypertrophy and Osteoarthritis in Mice by Inhibiting Sik3

Yasuhito Yahara, Hiroshi Takemori, Minoru Okada, Azuma Kosai, Akihiro Yamashita, Tomohito Kobayashi, Kaori Fujita, Yumi Itoh, Masahiro Nakamura, Hiroyuki Fuchino, Nobuo Kawahara, Naoshi Fukui, Akira Watanabe, etc.

Nat Commun. 2016 Mar 24;7:10959.

PMID: 27009967

Abstract:

Osteoarthritis is a common debilitating joint disorder. Risk factors for osteoarthritis include age, which is associated with thinning of articular cartilage. Here we generate chondrocyte-specific salt-inducible kinase 3 (Sik3) conditional knockout mice that are resistant to osteoarthritis with thickened articular cartilage owing to a larger chondrocyte population. We also identify an edible Pteridium aquilinum compound, pterosin B, as a Sik3 pathway inhibitor. We show that either Sik3 deletion or intraarticular injection of mice with pterosin B inhibits chondrocyte hypertrophy and protects cartilage from osteoarthritis. Collectively, our results suggest Sik3 regulates the homeostasis of articular cartilage and is a target for the treatment of osteoarthritis, with pterosin B as a candidate therapeutic.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP34175967	Pterosin B		34175-96-7	Price

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