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[Pulmonary Carcinoids and Carcinoids of the Small Intestine]

[Pulmonary Carcinoids and Carcinoids of the Small Intestine]

K S Winter, C J Auernhammer, A Todica, J Ricke, C Cyran

Radiologe. 2019 Nov;59(11):968-974.

PMID: 31570965

Abstract:

Clinical/methodical issue:
Pulmonary carcinoids and carcinoids of the small intestine (jejunum and ileum) are often asymptomatic and can affect various parts of the body, which makes diagnosis difficult.
Standard radiological methods:
Contrast-enhanced computed tomography (CE-CT) is commonly used for primary diagnostics. In case of concomitant pulmonary consolidation (e.g., atelectasis or pneumonia), tumor lesions can be obscured. In addition, differentiation between atypical (AC) and typical carcinoids (TC) is not possible using CT. Small tumors of the small intestine are easily overlooked (sensitivity: 50-85%, specificity: 25-97%, based on the literature). Additional functional imaging evaluation using hybrid imaging techniques can be applied, e.g., positron emission tomography/computed tomography (PET/CT).
Methodical innovations/performance:
Depending on the histological characteristics of the tumor, PET/CT scans can be performed with different tracers. Since most carcinoids (e.g., TC) express somatostatin receptors (SSR), 68 gallium-radiolabeled PET tracers (e.g. 68 Ga-DOTA-TOC) are commonly used (sensitivity: 88-93%, specificity: 88-95%, based on the literature). Poorly differentiated carcinoids (e.g., AC) demonstrate lower SSR expression; thus, use of 18F‑FDG (sensitivity: 37-72%, based on the literature) is indicated. In principle, these methods enable a noninvasive prognostic differentiation based on SSR expression and 18F‑FDG uptake. However, the diagnosis must always be histologically confirmed.
Achievements/practical recommendations:
Hybrid imaging with CE-CT and PET is useful to detect pulmonary carcinoids and carcinoids of the small intestine, respectively, and can be utilized for primary diagnostics and restaging.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS23301	TOC standard			Price

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