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Purification and Identification of Endogenous Anti-Opioid Substances From Bovine Brain

Purification and Identification of Endogenous Anti-Opioid Substances From Bovine Brain

S Kaneko, S Tamura, H Takagi

Biochem Biophys Res Commun. 1985 Jan 16;126(1):587-93.

PMID: 2982380

Abstract:

Two fractions with high potency for reversing the inhibitory effect of Met-enkephalin on the electrically induced contractility of guinea-pig ileum have been purified from bovine brain extract. Unexpectedly, one isolated peptide was identified as [Val5]-angiotensin I and the other fraction was [Val5]-angiotensin II, as judged by chromatographic comparisons on HPLC and amino acid analysis. Since angiotensins did not affect opioid binding to brain membrane, we consider that angiotensins may act as physiological antagonists to the opioid system in the brain, as well as in the guinea-pig ileum.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP484435	[Val5]-Angiotensin I bovine		484-43-5	Price

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