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Puromycin: Effect on Memory of Mice When Injected With Various Cations

J B Flexner, L B Flexner

Science. 1969 Sep 12;165(3898):1143-4.

PMID: 5801598

Abstract:

Puromycin dihydrochloride neutralized with bases of potassium, lithium, calcium, or magnesium fails to block expression of memory of maze learning in mice, unlike puromycin neutralized with NaOH. This failure may be due to cationic binding at anionic membrane sites with a resultant exclusion of sufficient peptidyl-puromycin to make it ineffective in blocking memory.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP58582-A Puromycin dihydrochloride Puromycin dihydrochloride 58-58-2 Price
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