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PVP Formulated Fullerene (C60) Increases Rho-kinase Dependent Vascular Tissue Contractility in Pregnant Sprague Dawley Rats

PVP Formulated Fullerene (C60) Increases Rho-kinase Dependent Vascular Tissue Contractility in Pregnant Sprague Dawley Rats

Achini K Vidanapathirana, Leslie C Thompson, Erin E Mann, Jillian T Odom, Nathan A Holland, Susan J Sumner, Li Han, Anita H Lewin, Timothy R Fennell, Jared M Brown, Christopher J Wingard

Reprod Toxicol. 2014 Nov;49:86-100.

PMID: 25088243

Abstract:

Pregnancy is a unique physiological state, in which C60 fullerene is reported to be distributed in both maternal and fetal tissues. Tissue distribution of C60 differs between pregnant and non-pregnant states, presumably due to functional changes in vasculature during pregnancy. We hypothesized that polyvinylpyrrolidone (PVP) formulated C60 (C60/PVP) increases vascular tissue contractility during pregnancy by increasing Rho-kinase activity. C60/PVP was administered intravenously to pregnant and non-pregnant female Sprague Dawley rats. Vascular responses were assessed using wire myography 24h post-exposure. Increased stress generation was observed in uterine artery, thoracic aorta and umbilical vein. Rho-Rho-kinase mediated force maintenance was increased in arterial segments from C60/PVP exposed pregnant rats when compared to PVP exposed rats. Our findings suggest that intravenous exposure to C60/PVP during pregnancy increases vascular tissue contractility of the uterine artery through elements of Rho-Rho-kinase signaling during late stages of pregnancy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP99685968	Fullerene-C60		99685-96-8	Price

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