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Quantitation of Carbenicillin Disodium, Cefazolin Sodium, Cephalothin Sodium, Nafcillin Sodium, and Ticarcillin Disodium by High-Pressure Liquid Chromatography

Quantitation of Carbenicillin Disodium, Cefazolin Sodium, Cephalothin Sodium, Nafcillin Sodium, and Ticarcillin Disodium by High-Pressure Liquid Chromatography

V D Gupta, K R Stewart

J Pharm Sci. 1980 Nov;69(11):1264-7.

PMID: 7452453

Abstract:

High-pressure liquid chromatographic (HPLC) methods for the quantitation of carbenicillin, cefazolin, cephalothin, nafcillin, and ticarcillin were developed. The stability of 2% solutions of the antibiotics in normal saline and in 5% dextrose in water were studied at 24 and 5 degrees. The assays were conducted using a previously reported colorimetric method, and some assays also were performed using HPLC. For discolored solutions of cephalothin, the colorimetric method was not stability indicating. The percent relative standard deviations by HPLC based on six injections were 1.69, 0.94, 1.30, 1.59, and 1.6 for carbenicillin, cefazolin, cephalothin, nafcillin, and ticarcillin, respectively. Both carbenicillin and ticarcillin apparently may be mixtures of two isomers at equilibrium with each other. The shelflives recommended by the manufacturers at 5 degrees may be too conservative.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP58719	Cephalothin sodium		58-71-9	Price

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