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Quantitative 31P-NMR Spectroscopy for the Determination of Fosfomycin and Impurity A in Pharmaceutical Products of Fosfomycin Sodium or Calcium

Haipeng Jiang, Hong Chen, Nian Cai, Jing Zou, Xiulian Ju

Magn Reson Chem. 2015 Jun;53(6):454-9.

PMID: 25855198

Abstract:

A quantitative 31P-NMR method for the determination of fosfomycin and impurity A in pharmaceutical products of fosfomycin sodium or calcium has been developed. In this method, coaxial inserts containing trimethyl phosphate are used as external standard. The method is convenient and robust, and gives both high accuracy and precision. It is shown that an accurate determination is possible using different probes and coaxial inserts.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP26016999 Fosfomycin sodium Fosfomycin sodium 26016-99-9 Price
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