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Quantitative Analysis of Methacycline Hydrochloride by Direct Potentiometry Using the Internal Solid Contact Sensor

Quantitative Analysis of Methacycline Hydrochloride by Direct Potentiometry Using the Internal Solid Contact Sensor

Xian Xiang Sun, Hassan Y Aboul-Enein

Anal Sci. 2007 Feb;23(2):231-3.

PMID: 17297239

Abstract:

An internal solid contact sensor (ISCS) for the determination of methacycline hydrochloride (MC.Cl), Pt/PPy/PVC(MC-PT), is described, based on the use of conducting poly(pyrrole) (PPy) as solid contact material and MC-phosphotungstate (PT) as the ion exchanger and dibutyl phthalate (DBP) as the plasticizer. A direct potentiometric method for the quantitative analysis of MC.Cl is also described. Under the condition of pH 2.7, the linear concentration range, slope (25 degrees C) and detection limit of the sensor are 6.4 x 1.0(-6) - 3.0 x 1.0(-3) M, 52.4 +/- 0.2 mV/decade and 4.4 x 1.0(-6) M, respectively. The response time is <5 s. The determinations of MC.Cl in tablets were carried out by direct potentiometry. The average recovery and relative standard deviation are 100.1 and 0.7% (n = 4), respectively.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3963959-B	Methacycline hydrochloride		3963-95-9	Price

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