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Quantitative Determinations of Codeine Phosphate, Guaifenesin, Pheniramine Maleate, Phenylpropanolamine Hydrochloride, and Pyrilamine Maleate in an Expectorant by High-Pressure Liquid Chromatography

V D Gupta, A G Ghanekar

J Pharm Sci. 1977 Jun;66(6):895-7.

PMID: 874803

Abstract:

The quantitative determinations of codeine phosphate, guaifenesin, pheniramine maleate, phenylpropanolamine hydrochloride, and pyrilamine maleate in a liquid dosage form are described. All active and inactive ingredients (sodium benzoate and FD&C Yellow No. 5 dye) can be separated with high-pressure liquid chromatography except the two antihistamines, pheniramine maleate and pyrilamine maleate. Pheniramine maleate is determined colorimetrically, and pyrilamine maleate is determined either by difference or spectrophotometrically. The methods are simple short, accurate, and precise. The standard deviations are reported.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP59336-A Pyrilamine maleate Pyrilamine maleate 59-33-6 Price
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