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Quisqualic Acid-Induced Neurotoxicity Is Protected by NMDA and non-NMDA Receptor Antagonists

Quisqualic Acid-Induced Neurotoxicity Is Protected by NMDA and non-NMDA Receptor Antagonists

K S Pai, V Ravindranath

Neurosci Lett. 1992 Aug 31;143(1-2):177-80.

PMID: 1359473

Abstract:

Quisqualic acid-mediated excitotoxicity has been attributed essentially to the activation of non-N-methyl-D-aspartate (non-NMDA) receptors. In the present study we demonstrate the possible involvement of both NMDA and non-NMDA receptors in quisqualic acid-induced toxicity in mouse brain slices, in vitro. Incubation of mouse brain sagittal slices with various concentrations of quisqualic acid resulted in significant increase in the leakage of lactate dehydrogenase and potassium from the slices into the medium. Prior incubation of mouse brain slices with NMDA (MK-801 or AP7) or non-NMDA receptor antagonists (GDEE or quinoxalinediones) protected against quisqualic acid-mediated toxicity. Slices prepared from animals pretreated in vivo with MK-801 (5 mg/kg b.wt.) were also resistant to the toxic effects of quisqualic acid, indicating the possible involvement of NMDA receptors in quisqualic acid toxicity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP52809071	Quisqualic acid		52809-07-1	Price

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