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(R)-α-Lipoyl-Gly-l-Pro-l-Glu Dimethyl Ester as Dual Acting Agent for the Treatment of Alzheimer's Disease

(R)-α-Lipoyl-Gly-l-Pro-l-Glu Dimethyl Ester as Dual Acting Agent for the Treatment of Alzheimer's Disease

Lisa Marinelli, Erika Fornasari, Antonio Di Stefano, Hasan Turkez, Mehmet Enes Arslan, Piera Eusepi, Michele Ciulla, Ivana Cacciatore

Neuropeptides. 2017 Dec;66:52-58.

PMID: 28993014

Abstract:

In this study, effects of LA-GPE (R-α-Lipoyl-Gly-l-Pro-l-Glu dimethyl ester) and GPE (Gly-L-Pro-L-Glu) on the cytotoxic action of Aβ1-42 were tested with differentiated human neuroblastoma SH-SY5Y cells as cellular Alzheimer model via measurements of mitochondrial viability (MTT assay) and lactate dehydrogenase release (LDH assay). Effects of LA-GPE and GPE on acetylcholinesterase (AChE) activity, total antioxidant capacity (TAC) and total oxidative status (TOS) levels, and neural cell apoptosis and necrosis were also determined. In addition, biological safety of these novel formulations was evaluated in human blood cells using different cytotoxicity and genotoxicity assays. Our results indicated that both compounds could block Aβ1-42 induced cell death. LA-GPE reduced Aβ-induced AChE activity and oxidative stress, suggesting it as a multifunctional compound potentially valuable for the treatment of Alzheimer's disease (AD).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP32302764	Gly-Pro-Glu		32302-76-4	Price

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