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Rabbit Anti-Idiotypic Antibodies Raised Against Monoclonal Anti-Morphine IgG Block Mu & Delta Opiate Receptor Sites

J A Glasel, W E Myers

Life Sci. 1985 Jul 1;36(26):2523-9.

PMID: 2989638

Abstract:

Rabbit antibodies have been raised against murine monoclonal anti-morphine Fab fragments. Following affinity purification, these antibodies competitively inhibit morphine binding to anti-morphine monoclonal antibodies, yet do not recognize normal mouse IgGs, suggesting that the antibodies produced are anti-idiotypic with respect to the anti-morphine IgG. More importantly, the purified antibodies competitively inhibit binding of morphine, naloxone, and D-ala-2-D-leu-5-enkephalin to rat brain opiate receptors.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
IAR42416665 Anti-phospho-Opioid Receptor-δ (pSer363) antibody produced in rabbit Anti-phospho-Opioid Receptor-δ (pSer363) antibody produced in rabbit Price
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