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Radiation Damage on Langmuir Monolayers of the Anionic 1.2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (Sodium salt)(DPPG) Phospholipid at the air-DNA Solution Interface

Radiation Damage on Langmuir Monolayers of the Anionic 1.2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (Sodium salt)(DPPG) Phospholipid at the air-DNA Solution Interface

Paulo J Gomes, Amélia M P S Gonçalves da Silva, Paulo A Ribeiro, Osvaldo N Oliveira Jr, Maria Raposo

Mater Sci Eng C Mater Biol Appl. 2016 Jan 1;58:576-9.

PMID: 26478346

Abstract:

The resilience of cells to ultraviolet (UV) irradiation is probably associated with the effects induced in biological molecules such as DNA and in the cell membrane. In this study, we investigated UV damage to the anionic 1.2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (sodium salt) (DPPG) phospholipid, which is an important component of cell membranes. In films cast from DPPG emulsions, UV irradiation induced cleavage of C-O, C=O and -PO(2-) bonds, while in Langmuir monolayers at the air/water interface representing the cell membrane this irradiation caused the monolayer stability to decrease. When DNA was present in the subphase, however, the effects from UV irradiation were smaller, since the ionic products from degradation of either DPPG or DNA stabilize the intact DPPG molecules. This mechanism may explain why UV irradiation does not cause immediate cell collapse, thus providing time for the cellular machinery to repair elements damaged by UV.

Chemicals Related in the Paper:

Catalog Number	Product Name	CAS Number	Price
AP1241726124	1,2-Dierucoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt	1241726-12-4	Price
AP200880428	1,2-Distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt	200880-42-8	Price
AP268550954	2-Oleoyl-1-palmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt	268550-95-4	Price
AP67232819	1,2-Dipalmitoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt	67232-81-9	Price

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