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Radical Cystectomy for pT1 Urothelial Carcinoma of Bladder Not Amenable to TURBT: Long-term Results

Radical Cystectomy for pT1 Urothelial Carcinoma of Bladder Not Amenable to TURBT: Long-term Results

Baojie Ma, Yu Li, Saisai Han, Xingkang Jiang, Yang Zhao, Jianing Guo, Changyi Quan, Yuanjie Niu

Eur J Surg Oncol. 2019 Oct;45(10):1993-1999.

PMID: 31327502

Abstract:

Purpose:
This study sought to identify factors associated with survival of pT1 urothelial carcinoma of bladder (UCB) after radical cystectomy (RC).
Methods:
This study consists of 114 pT1 UCB [primary 83, recurrent 31, none were amenable to transurethral resection (TUR)] treated by radical cystectomy. Survival analysis using Cox regression tests were performed to identify factors associated with survival of pT1 UCB after RC.
Results:
Pelvic lymph node (LN) status, age and lymphovascular invasion (LVI) are associated with survival of pT1 UCB after RC; recurrent pT1 UCB of high grade origin (HGO) tends to have poorer CSS than primary pT1 UCB or recurrent pT1 UCB of low grade origin (LGO) (5-year and 10-year CSS rates was 75% and 73% for primary cases; 77% and 77% for recurrent pT1 UCB of LGO; and 56% and 37% for recurrent pT1 UCB of HGO, p = 0.078).
Conclusions:
LN status, age and LVI were significantly associated with survival of pT1 UCB after RC. Recurrent pT1 UCB of HGO should be managed with radical cystectomy in a timely fashion given that these cases tend to have poorer CSS than primary pT1 UCB after RC, even if they did not progress to muscle-invasive bladder cancer (MIBC).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP331002701	PT1		331002-70-1	Price

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