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Radioiodine Volatilization From Reformulated Sodium Iodide I-131 Oral Solution

Radioiodine Volatilization From Reformulated Sodium Iodide I-131 Oral Solution

L W Luckett, R E Stotler

J Nucl Med. 1980 May;21(5):477-9.

PMID: 7373420

Abstract:

By changing the pH and adding buffers, antioxidants, and stabilizers to a sodium iodide (I-131) oral solution, a reduced radioiodine volatilization was claimed by a commercial supplier of radiopharmaceuticals. This study compares the airborne radioactivity volatilized from the reformulated sodium iodide solution with that which became airborne from a previous formulation. Air samples were obtained from the fume hood's exhaust stack during initial venting, and from the breathing zones of physicians and technologists administering the solution to the patient. Analysis of the air samples indicates significant reduction in the airborne radioiodine following initial venting of the solution vial and during patient administration. Additionally, there has been a decline in the I-131 thyroid burdens for occupationally exposed personnel handling the reformulated sodium iodide solutions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP172035868	3-Thienylmagnesium iodide solution		172035-86-8	Price
AP46000106	1-Naphthylzinc iodide solution		46000-10-6	Price

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