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Radioprotective Effect of Vitamin E in Parotid Glands: A Morphometric Analysis in Rats

Radioprotective Effect of Vitamin E in Parotid Glands: A Morphometric Analysis in Rats

Carolina Cintra Gomes, Flávia Maria de Moraes Ramos-Perez, Danyel Elias da Cruz Perez, Pedro Duarte Novaes, Frab Norberto Bóscolo, Solange Maria de Almeida

Braz Dent J. 2013;24(3):183-7.

PMID: 23969903

Abstract:

The aim of this study was to evaluate the radioprotective effect of vitamin E on rat parotid glands by morphometric analysis. Sixty male rats were divided into 5 groups (n=6): control, in which animals received olive oil solution; olive oil/irradiated, in which animals received olive oil and were irradiated with a dose of 15 Gy of gamma radiation; irradiated, in which animals were irradiated with a dose of 15 Gy gamma radiation; vitamin E, which received α-tocopherol acetate solution; vitamin E/irradiated, which received α-tocopherol acetate solution before irradiation with a dose of 15 Gy gamma rays. Half of the animals were euthanized at 8 h, and the remaining at 30 days after irradiation. Both parotid glands were surgically removed and morphometric analysis of acinar cells was performed. Data were subjected to two-way ANOVA and Tukey's test (α=0.05). Morphometric analysis showed a significant reduction in the number of parotid acinar cells at 30 days in olive oil/irradiated and irradiated groups. In groups evaluated over time a significant reduction was shown at 30 days in olive oil/irradiated and irradiated groups, indicating that ionizing radiation caused tissue damage. The vitamin E/irradiated group presented more acinar cells than the irradiated group, but no statistically significant difference was observed (p>0.05). In conclusion, vitamin E seems to have failed as a radioprotective agent on acinar cells in rat parotid glands.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP52225204	Tocopheryl acetate (Vitamin E acetate) solution		52225-20-4	Price
AP54284	(+)-γ−Tocopherol (Vitamin E) solution		54-28-4	Price

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