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Radiosynthesis and reactivity of N-[ 11 C]methyl carbamoylimidazole

Manikandan Kadirvel, Déborah Cardoso, Sally Freeman, Gavin Brown

J Radioanal Nucl Chem. 2018;317(2):977-984.

PMID: 30100651

Abstract:

N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70-74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP72025184 Methyl myristelaidate Methyl myristelaidate 72025-18-4 Price
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