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Randomized Clinical Trial on Preventing Root Caries Among Community-Dwelling Elders

Randomized Clinical Trial on Preventing Root Caries Among Community-Dwelling Elders

R Li, E C M Lo, B Y Liu, M C M Wong, C H Chu

JDR Clin Trans Res. 2017 Jan;2(1):66-72.

PMID: 30938645

Abstract:

Dental root caries is a common disease among elders. More efforts on preventing this disease are needed. Silver diammine fluoride (SDF) is known to prevent dental caries in primary teeth. However, clinical evidence of its efficacy in preventing root surface caries is limited. This clinical trial aimed to compare the effectiveness of SDF in preventing root caries among elders in a water fluoridated area. A total of 323 elders who had at least 5 teeth with exposed root surfaces and who had self-care ability were randomly allocated into 3 intervention groups: group 1 (placebo control), annual application of tonic water; group 2, annual application of SDF solution; group 3, annual application of SDF solution, immediately followed by potassium iodide (KI) solution. Oral hygiene instructions and fluoride toothpaste were provided to all subjects. Status of dental root surface was assessed every 6 mo by the same independent examiner. After 30 mo, 257 (79.6%) elders were reviewed. The mean numbers of root surface with new caries experience in the control, SDF, and SDF/KI groups were 1.1, 0.4, and 0.5, respectively (analysis of variance, P < 0.001). Scheffe's multiple comparison showed that elders who received placebo developed more new root caries lesions ( P < 0.05), while the difference between the SDF and SDF/KI groups was not statistically significant ( P > 0.05). Moreover, elders who had higher visible plaque index scores at 30-mo examination (analysis of covariance, P < 0.001) and those who had higher baseline DMFT scores (analysis of covariance, P = 0.005) developed more new root caries. It is concluded that annual application of SDF or SDF/KI solution is effective in preventing root caries among community-dwelling elders in a fluoridated area ( ClinicalTrials.gov NCT02360124). Knowledge Transfer Statement: Annual topical application of silver diammine fluoride or silver diammine fluoride / potassium iodide solution is effective in preventing dental root surface caries among community-dwelling elders in a fluoridated area.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP312692867	3,5-Dichlorophenylzinc iodide solution		312692-86-7	Price
AP312692958	2,4-Dimethylphenylzinc iodide solution		312692-95-8	Price

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