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Randomized Study of Minocycline and Edetic Acid as a Locking Solution for Central Line (Port-A-Cath) in Children With Cancer

Randomized Study of Minocycline and Edetic Acid as a Locking Solution for Central Line (Port-A-Cath) in Children With Cancer

Julieta Maria Ferreira Chacon, Emília Hato de Almeida, Regina de Lourdes Simões, Viviane Lazzarin C Ozório, Benaia Cândida Alves, Maria Lydia Mello de Andréa, Marcela Santiago Biernat, João Carlos Biernat

Chemotherapy. 2011;57(4):285-91.

PMID: 21778716

Abstract:

Background:
Contamination of central catheters is frequent, and biofilm perpetuates infections. Heparin does not protect against infections because it has no antibiotic action. Minocycline and edetic acid (M-EDTA), a potent calcium chelating agent that destroys bacterial and fungal cell membrane and disrupts biofilm, may be an alternative to allow the associated antibiotic to act locally at a high and safe concentration.
Methods:
Fifty children with cancer and a port-a-cath were followed up: 26 received heparin (group 1) and 24 M-EDTA (group 2). A total of 762 serial prospective blood cultures were obtained, 387 from group 1 and 375 from group 2.
Results:
In group 1 (heparin), 19 blood cultures were positive, and infection incidence was 73.1% (19/26 ports). In group 2 (M-EDTA), 5 blood cultures were positive, and the incidence rate was 20.8% (5/24 ports).
Conclusion:
M-EDTA, compared with heparin, prevents and treats catheter infections, and is a promising alternative to decrease sepsis during chemotherapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP60004	Edetic acid		60-00-4	Price

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