0

Rapid Gas Chromatographic Determination of Ethylene Oxide, Ethylene Chlorohydrin, and Ethylene Glycol Residues in Rubber Catheters

R J Muzeni

J Assoc Off Anal Chem. May-Jun 1985;68(3):506-8.

PMID: 4019375

Abstract:

Isothermal gas chromatography with flame ionization detection was used to determine residual ethylene oxide (EtO), ethylene chlorohydrin, and ethylene glycol in soft rubber catheters that had been sterilized with EtO. Catheter samples were extracted by shaking with carbon disulfide, and the extract was analyzed on a 3% Carbowax 20M on 80-100 mesh Chromosorb 101 column, using nitrogen as the carrier gas. Ten replicate injections of a mixed standards solution gave coefficients of variation of 1.91, 1.23, and 4.74% for EtO, ethylene chlorohydrin, and ethylene glycol, respectively. A linear response was obtained with concentrations ranging from 1.0 to 7.9 micrograms EtO, 14.0 to 88.0 micrograms ethylene chlorohydrin, and 31.0 to 98.5 micrograms ethylene glycol. The proposed method detected as little as 0.5, 5.0, and 16.5 ng EtO, ethylene chlorohydrin, and ethylene glycol, respectively.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP84508463 Ethylene oxide-13C2 Ethylene oxide-13C2 84508-46-3 Price
qrcode