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Rat Hippocampal Proteomic Alterations Following Intrahippocampal Injection of Amyloid Beta Peptide (1-40)

Rat Hippocampal Proteomic Alterations Following Intrahippocampal Injection of Amyloid Beta Peptide (1-40)

Xiang Shi, Xiaoguang Lu, Libin Zhan, Li Liu, Mingzhong Sun, Xiaoyang Gong, Hua Sui, Xinping Niu, Shuqing Liu, Luping Zheng, Jing Chen, Yan Zhou

Neurosci Lett. 2011 Aug 15;500(2):87-91.

PMID: 21699958

Abstract:

Amyloid beta peptide 1-40 (Aβ(1-40)) is closely associated with the progressive neuronal loss and cognitive decline observed in Alzheimer's disease (AD). This study aimed to establish a proteomic strategy for the profiling of AD tissues for disease-specific changes in protein abundance. Intrahippocampal injection of Aβ(1-40) induced spatial memory and learning decline in rats. Proteomic analysis revealed the changes in protein expression in the rat hippocampus treated with Aβ(1-40). Four proteins of interest which was in abundance was significantly altered in Aβ(1-40)-treated rats were identified by peptide mass fingerprint (PMF). These proteins corresponded to synapsin Ib, protein disulfide-isomerase A3 precursor, tubulin β chain and ATP synthase β subunit. Our results provide new insights into the relationship between Aβ and the pathogenesis of AD, and suggest potential targets for the therapy of AD.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248095	Amyloid β 1-40 rat			Price

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