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Rational Design of Biologically Important Chemosensors: A Novel Receptor for Selective Recognition of Acetylcholine Over Ammonium Cations

Rational Design of Biologically Important Chemosensors: A Novel Receptor for Selective Recognition of Acetylcholine Over Ammonium Cations

Sunggoo Yun, Young-Ok Kim, Dongwook Kim, Heon Gon Kim, Hyejae Ihm, Jung Kyung Kim, Chi-Wan Lee, Woo Jin Lee, Jungjoo Yoon, Kyung Seok Oh, Juyoung Yoon, Su-Moon Park, Kwang S Kim

Org Lett. 2003 Feb 20;5(4):471-4.

PMID: 12583746

Abstract:

[structure: see text] In consideration of competition between cation-pi and hydrogen bond interaction forces, we designed a novel receptor, 1,3,5-tris(pyrrolyl)benzene, which shows high selectivity for acetylcholine (ACh). The selectivity of the receptor for ACh over other ammonium cations is demonstrated by the ion-selective electrode (ISE) method in buffer solution. The binding free energy of the receptor with ACh in chloroform solution is measured to be 3.65 kcal/mol in the presence of chloride anion by nuclear magnetic resonance spectroscopy, and that in water is estimated to be much greater ( approximately 6 kcal/mol).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP12125029-B	Ammonium ion solution for ISE		12125-02-9	Price

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