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RC-3095, a bombesin/gastrin-releasing Peptide Receptor Antagonist, Impairs Aversive but Not Recognition Memory in Rats

RC-3095, a bombesin/gastrin-releasing Peptide Receptor Antagonist, Impairs Aversive but Not Recognition Memory in Rats

Rafael Roesler, Márcia I Kopschina, Renato M Rosa, João Antônio Pêgas Henriques, Diogo Onofre Souza, Gilberto Schwartsmann

Eur J Pharmacol. 2004 Feb 13;486(1):35-41.

PMID: 14751406

Abstract:

Bombesin and its mammalian equivalent, gastrin-releasing peptide (GRP), stimulate cell proliferation and are involved in the pathogenesis of several types of human cancer. Bombesin-like peptides also display neuroendocrine activities and regulate neural function. In the present study, we evaluated the effects of the bombesin/GRP receptor antagonist (D-Tpi(6), Leu(13) psi[CH(2)NH]-Leu(14)) bombesin-(6-14) (RC-3095), experimental antitumor drug, on memory in rats. Adult female Wistar rats were treated with an intraperitoneal injection of RC-3095 (0.2, 1.0 or 5.0 mg/kg) 30 min before training in either inhibitory avoidance or novel object recognition tasks. Retention test trials were carried out 1.5 (short-term memory) or 24 h (long-term memory) after training. RC-3095 at the doses of 0.2 or 1.0 mg/kg, but not at the dose of 5.0 mg/kg, impaired both short- and long-term inhibitory avoidance retention, but did not affect recognition memory. The memory-impairing effect of RC-3095 could not be attributed to alterations in sensorimotor functions. The results show that the antitumor drug/GRP antagonist RC-3095 impairs formation of aversive memory.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP138147781	RC-3095		138147-78-1	Price

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