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Reactive Oxygen Species (ROS) Reduce the Expression of BRAK/CXCL14 in Human Head and Neck Squamous Cell Carcinoma Cells

Reactive Oxygen Species (ROS) Reduce the Expression of BRAK/CXCL14 in Human Head and Neck Squamous Cell Carcinoma Cells

Yojiro Maehata, Shigeyuki Ozawa, Kyo Kobayashi, Yasumasa Kato, Fumihiko Yoshino, Chihiro Miyamoto, Kazuhito Izukuri, Eiro Kubota, Ryu-Ichiro Hata, Masaichi-Chang-Il Lee

Free Radic Res. 2010 Aug;44(8):913-24.

PMID: 20815772

Abstract:

The present study investigated the effects of oxidative stress induced by reactive oxygen species (ROS), such as hydrogen peroxide (H(2)O(2)) and hydroxyl radical (HO(*)), on the expression of both BRAK , which is also known as non-ELR motif angiostatic CXC chemokine ligand 14 (CXCL14), in head and neck squamous cell carcinoma (HNSCC) cells. When HNSCC cells were cultured in the presence of ROS, the expression of BRAK was significantly decreased whereas that of IL-8 was increased. Interestingly, the effects on the expression of both genes in HNSCC cells were much greater with HO(blacksquare, square, filled) than with H(2)O(2). The effects of ROS on both BRAK and IL-8 expression were attenuated by pre-treatment with N-acetyl-L-cysteine (NAC), epidermal growth factor receptor (EGFR), and mitogen-activated protein kinase (MAPK) inhibitors. These results indicate that oxidative stress induced by H(2)O(2) or HO(*) stimulates angiogenesis and tumuor progression by altering the gene expression of BRAK and IL-8 via the EGFR/MEK/ERK pathway in human HNSCC cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248644	BRAK (CXCL14) human			Price

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