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Recent Advances of Tetrazole Derivatives as Potential Anti-Tubercular and Anti-Malarial Agents

Chuan Gao, Le Chang, Zhi Xu, Xiao-Fei Yan, Chao Ding, Feng Zhao, Xiang Wu, Lian-Shun Feng

Eur J Med Chem. 2019 Feb 1;163:404-412.

PMID: 30530192

Abstract:

Tetrazole, a bioisostere of the carboxylic acid group, can replace the carboxyl group in drugs to increase the lipophilicity, bioavailability and reduce side effects. Tetrazole derivatives possess a broad-spectrum of biological properties including anti-tubercular and anti-malarial activities, and some tetrazole-based compounds have already been used in clinics for the treatment of various diseases. Therefore, tetrazole is an important pharmacophore in the development of new drugs. This review covers the recent advances of tetrazole derivatives as potential anti-tubercular and anti-malarial agents, and the structure-activity relationship is also discussed for the further rational design of tetrazole derivatives.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP916923109 Mephetyl tetrazole Mephetyl tetrazole 916923-10-9 Price
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