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Recent Progress in Sodium Channel Modulators for Pain

Sharan K Bagal, Mark L Chapman, Brian E Marron, Rebecca Prime, R Ian Storer, Nigel A Swain

Bioorg Med Chem Lett. 2014 Aug 15;24(16):3690-9.

PMID: 25060923

Abstract:

Voltage-gated sodium channels (Navs) are an important family of transmembrane ion channel proteins and Nav drug discovery is an exciting field. Pharmaceutical investment in Navs for pain therapeutics has expanded exponentially due to genetic data such as SCN10A mutations and an improved ability to establish an effective screen sequence for example IonWorks Barracuda®, Synchropatch® and Qube®. Moreover, emerging clinical data (AZD-3161, XEN402, CNV1014802, PF-05089771, PF-04531083) combined with recent breakthroughs in Nav structural biology pave the way for a future of fruitful prospective Nav drug discovery.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1079400079 PF-04531083 PF-04531083 1079400-07-9 Price
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