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Recurrent Idiotopes and Internal Images

Recurrent Idiotopes and Internal Images

N K Jerne, J Roland, P A Cazenave

EMBO J. 1982;1(2):243-7.

PMID: 6985352

Abstract:

A rabbit was immunized with rabbit immunoglobulins of a different allotype. The anti-allotypic antibodies produced by this rabbit were used to immunize a second rabbit which produced anti-idiotypic antibodies. To explain the occurrence, among these anti-idiotypic antibodies, of "internal images" of the original immunizing allotype, a restricted and a more general hypothesis are developed. The first assumes that B-cells can be triggered when idiotopes on their receptor molecules are recognized by the paratopes of the immunizing antibody. The second denies the existence of a specially constructed combining site on the variable domain of an antibody molecule.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42412382	Anti-RAIDD, Internal Domain antibody produced in rabbit			Price

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