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Redox/pH Dual Stimuli-Responsive Degradable Salecan-g-SS-poly(IA-co-HEMA) Hydrogel for Release of Doxorubicin

Redox/pH Dual Stimuli-Responsive Degradable Salecan-g-SS-poly(IA-co-HEMA) Hydrogel for Release of Doxorubicin

Xinyu Hu, Yongmei Wang, Liangliang Zhang, Man Xu, Wei Dong, Jianfa Zhang

Carbohydr Polym. 2017 Jan 2;155:242-251.

PMID: 27702509

Abstract:

Salecan is a novel water-soluble extracellular β-glucan and possesses excellent physicochemical and biological properties. Here, redox/pH dual stimuli-responsive hydrogel based on Salecan grafted with itaconic acid (IA) and 2-hydroxyethyl methacrylate (HEMA) were prepared using disulfide-functionalized crosslinker N,N-bis(acryloyl)cystamine (BAC) for controlled drug delivery. The introduction of carboxylic groups endows the system with pH-sensitive character, swelling behavior of the hydrogel was conducted by changing the pH and Salecan content. It was demonstrated that DOX was efficiently loaded into the hydrogels and released in a controlled fashion via pH-control and swelling-shrinking mechanism. More importantly, DOX-loaded hydrogels showed dose dependent cytotoxicity toward A549 cell, and efficient cell killing was observed. Furthermore, a key point of this study was that the presence of disulfide linkage in system favored the degradation of hydrogels in the reductive environment. These results highlight the potential of Salecan-g-SS-poly(IA-co-HEMA) hydrogel as a novel system for the controlled release of anti-cancer drugs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP60984578	N,N′-Bis(acryloyl)cystamine		60984-57-8	Price

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