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Reduction in Microalbuminuria by Calcium Channel Blockers in Patients With Type 2 Diabetes Mellitus and hypertension-A Randomized, Open-Label, Active-Controlled, Superiority, Parallel-Group Clinical Trial

Reduction in Microalbuminuria by Calcium Channel Blockers in Patients With Type 2 Diabetes Mellitus and hypertension-A Randomized, Open-Label, Active-Controlled, Superiority, Parallel-Group Clinical Trial

You-Cheol Hwang, Kun-Ho Yoon, Bong-Soo Cha, Kwan-Woo Lee, Hak Chul Jang, Kyung Wan Min, Choon Hee Chung, Moon-Kyu Lee

Int J Clin Pract. 2017 Sep;71(9):e12987.

PMID: 28840637

Abstract:

Background:
It has been suggested that renoprotection with calcium channel blockers (CCBs) may differ. This study aimed to compare the anti-proteinuric effect of different CCBs in patients with type 2 diabetes (T2D).
Methods:
A multicentre, randomized, open-label, active-controlled study was performed in seven centres in Korea. A total of 74 patients with T2D and microalbuminuria treated with renin-angiotensin system (RAS) blockers were randomized to a cilnidipine 10 mg treatment (n=38) or amlodipine 5 mg treatment (n=36).
Results:
Urine albumin to creatinine ratio (ACR) reduction was similar between the two groups at 12 weeks (-53.0±123.2 mg/g in cilnidipine group and -35.7±83.6 mg/g in amlodipine group, P=.29) or 24 weeks (-57.3±106.9 mg/g in cilnidipine group and -20.0±110.4 mg/g in amlodipine group, P=.24). In a subgroup analysis, cilnidipine treatment showed a larger ACR reduction than amlodipine treatment at 12 weeks (-84.7±106.8 mg/g in cilnidipine group and -9.5±79.2 mg/g in amlodipine group, P=.01) and 24 weeks (-84.0±111.7 mg/g in cilnidipine group and 14.6±119.4 mg/g in amlodipine group, P=.008), particularly in patients with a longer duration of diabetes more than 10 years.
Conclusions:
Cilnidipine did not show any additional anti-albuminuric effect compared with amlodipine in patients with T2D and microalbuminuria treated with an RAS blocker. However, the anti-albuminuric effect of cilnidipine might differ according to the duration of diabetes.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP132203704	Cilnidipine		132203-70-4	Price

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