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Regional Pattern of Binding and c-Fos Induction by (R)- And (S)-citalopram in Rat Brain

Regional Pattern of Binding and c-Fos Induction by (R)- And (S)-citalopram in Rat Brain

Christian Thomsen, Lone Helboe

Neuroreport. 2003 Dec 19;14(18):2411-4.

PMID: 14663201

Abstract:

Citalopram is a racemic mixture of two stereoisomers, (R)- and (S)-citalopram. Both enantiomers were radiolabelled and used for in vitro receptor autoradiography in rat brain. High levels of specific [3H](S)-citalopram binding were observed in the amygdala complex, substantia nigra, superior colliculus and central grey. No specific binding of [3H](R)-citalopram was observed in any brain regions examined. S-citalopram induced a significant increase in c-Fos positive cells in central amygdala and in the bed nucleus of the stria terminalis (BST), compared to vehicle controls. A similar pattern of c-Fos activation was observed with (RS)-citalopram, sertraline and paroxetine, while (R)-citalopram did not increase c-Fos expression in these areas. The high affinity binding and apparent neuronal activation by (RS)-citalopram is thus confined to the (S)-enantiomer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP79617893	Sertraline hydrochloride racemic mixture		79617-89-3	Price

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