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Regulation of Human Decidual Cell Macrophage Inflammatory protein-1 Alpha (MIP-1 Alpha) Production by Inflammatory Cytokines

Regulation of Human Decidual Cell Macrophage Inflammatory protein-1 Alpha (MIP-1 Alpha) Production by Inflammatory Cytokines

D J Dudley, S Spencer, S Edwin, M D Mitchell

Am J Reprod Immunol. 1995 Oct;34(4):231-5.

PMID: 8579760

Abstract:

Problem:
Inflammation of human gestational tissues is a key pathophysiologic event in the genesis of infection-associated preterm labor. Human gestational tissues produce several inflammatory cytokines after stimulation with bacterial products. These include interleukin-1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF alpha), and IL-6. Another class of cytokines includes chemokines of the "C-C" subclassification such as macrophage inflammatory protein-1 alpha (MIP-1 alpha). The purpose of this study was to determine whether cultured human decidual cells produce MIP-1 alpha in response to other inflammatory cytokines.
Methods:
Various concentrations of IL-1 beta, TNF alpha, IL-6, and IL-4 were incubated with confluent monolayer cultures of decidual cells isolated from normal term placentae for 16 h at 37 degrees C, and MIP-1 alpha concentrations in culture supernatants were measured by ELISA.
Results:
We found that incubation of decidual cells with IL-1 beta, TNF alpha, and IL-4 resulted in significant concentration-dependent increases in MIP-1 alpha production. IL-6 had no effect on MIP-1 alpha production.
Conclusions:
Our data are the first to show that human decidual cells in culture produce MIP-1 alpha in response to other inflammatory cytokines. We suggest that decidual cell production of MIP-1 alpha is an important early event in the pathophysiology of infection-associated preterm labor.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413097	MIP-1 beta (CCL4) human			Price

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