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[Regulation of Syringin, Chlorogenic Acid and 1,5-dicaffeoylquinic Acid Biosynthesis in Cell Suspension Cultures of Saussurea Involucrata]

[Regulation of Syringin, Chlorogenic Acid and 1,5-dicaffeoylquinic Acid Biosynthesis in Cell Suspension Cultures of Saussurea Involucrata]

Ri-Dao Chen, Xiao Liu, Jian-Hua Zou, Lin Yang, Jun-Gui Dai

Zhongguo Zhong Yao Za Zhi. 2014 Jun;39(12):2275-80.

PMID: 25244758

Abstract:

Syringin, chlorogenic acid and 1,5-dicaffeoylquinic acid are three main bioactive ingredients in herbs of Saussurea involucrata with various pharmacological properties, while their contents are very low. In this study, the biosynthesis of syringin, chlorogenic acid and 1,5-dicaffeoylquinic acid in the cell suspension cultures of S. involucrata were regulated by feeding carbon sources and precursors, which resulted in a great increase of the contents and yields of the above three bioactive ingredients. After 16 days of fermentation, the yields of syringin, chlorogenic acid and 1,5-dicaffeoylquinic acid reached 339.0, 225.3, 512.7 mg x L(-1), respectively. Meanwhile, their contents increased up to 67.9, 1.9, 10.6 times of wild medicinal material, respectively. The results provided a solid basis for further studies on application of cell suspension cultures of S. involucrata for large-scale production of bioactive compounds syringin, chlorogenic acid and 1,5-dicaffeoylquinic acid.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS7931219	1,3-dimethylpyrazole-5-boronic acid			Price

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