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Relative Affinity and Specificity of Monoclonal Antibodies Against Prostate-Specific Antigen

Relative Affinity and Specificity of Monoclonal Antibodies Against Prostate-Specific Antigen

D C Jette, F T Kreutz, M R Suresh

Tumour Biol. 1999;20 Suppl 1:24-7.

PMID: 10628405

Abstract:

The relative affinities of a panel of antibodies submitted to the ISOBM TD-3 PSA Workshop were determined by direct-binding ELISA. The Workshop antibodies were also tested for reactivity with the prostate-specific antigen alpha1-antichymotrypsin complex (PSA-ACT) and cross-reactivity with porcine pancreatic kallikrein. There was a wide range of affinities observed for the panel of antibodies. Twelve antibodies failed to react with the PSA-ACT complex, and 1 antibody was found to recognize an epitope on ACT but not on PSA. Only 2 antibodies were found to react with porcine pancreatic kallikrein, a protein with 64% sequence homology with human glandular kallikrein-2 (hK2).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42414845	Prostate Specific Antigen-α1-Antichymotrypsin Complex human			Price

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