Home
Resources
Publications
Removal of Dihydroxy-Terminated Components From Monomethoxy-Terminated Poly(ethylene Glycol)

Removal of Dihydroxy-Terminated Components From Monomethoxy-Terminated Poly(ethylene Glycol)

Dean Lee, Iwao Teraoka

Biomaterials. 2003 Jan;24(2):329-36.

PMID: 12419635

Abstract:

A preparative method to remove dihydroxy-terminated components in a sample of presumably monomethoxy, monohydroxy-terminated poly(ethylene glycol) (PEG) is presented. Purification of the monomethoxy-terminated component allows one to prepare a diblock copolymer of PEG and poly(lactic acid) (PLLA) free of a PLLA-PEG-PLLA triblock copolymer in various biomedical applications of the copolymer. Efficiency of the purification is compared for high osmotic pressure chromatography (HOPC) and preparative size exclusion chromatography (SEC). In HOPC, various types of porous silica particles, surfaces, solvents, polymer concentrations have been screened for the optimal performance. It was found that HOPC is more efficient than SEC, especially HOPC of 30-40 wt% solutions in water by a column packed with acid-washed controlled pore glass is optimal in producing high-purity fractions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP68951939	Poly(dimethylsiloxane-co-diphenylsiloxane), dihydroxy terminated		68951-93-9	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: