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Renal Salt Wasting in Patients Treated With High-Dose Cisplatin, Etoposide, and Mitomycin in Patients With Advanced Non-Small Cell Lung Cancer

Renal Salt Wasting in Patients Treated With High-Dose Cisplatin, Etoposide, and Mitomycin in Patients With Advanced Non-Small Cell Lung Cancer

Y K Lee, D M Shin

Korean J Intern Med. 1992 Jul;7(2):118-21.

PMID: 1339077

Abstract:

Cisplatin has many toxic effects; emesis, impairment of renal function, myelosuppression, peripheral neuropathy, ototoxicity and renal tubular wasting. We used MVP regimen (Mitomycin C, Vp-16, and Cisplatin) in advanced Non-Small Cell Lung Cancer (NSCLC). Using hydration and prophylactic supplementation of sodium and potassium before and during chemotherapy, we have observed the development of hyponatremia in 48 courses (43%), hypokalemia in 23 courses and hypomagnesemia in 11 courses. Some patients showed abnormalities of renal function in 16 courses. All the electrolyte depletion and renal problem was corrected before next courses by hydration and replacement of the wasting. Frequent measurement of serum cation and appropriate replacement are recommended when high dose Cisplatin containing regimen is used in chemotherapy of neoplasms.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
ALP59917394	Vindesine sulfate salt hydrate		59917-39-4 (anhydrous)	Price

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