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Report: Palladium Glutathione, N-acetylcysteine, D-penicillamine Conjugation Chemistry

Report: Palladium Glutathione, N-acetylcysteine, D-penicillamine Conjugation Chemistry

Muhammad Mukhtiar, Syed Umer Jan, Muhammad Farid Khan, Naseem Ullah, Abid Hussain, Saifur Rehman, Muhammad Murtaza Qureshi

Pak J Pharm Sci. 2018 Jan;31(1):213-219.

PMID: 29348106

Abstract:

The metalloelement Palladium has a number of potential Pharmaco-clinical advantages. Palladium compounds have antiviral, antibacterial, neuroprotective and antitumor properties. However studies have also indicated some mild to serious toxic effects of Palladium metalloelements. Biothiols are important antioxidants that provide protection against metals toxicity. The interaction of metalloelements with biothiols can provide valuable information about the level of toxicity of the metalloelements and about the protective role of biothiols thereof. In this piece of work the effect of salt and complexes of Palladium on the status of different thiols (GSH, NAC, and D-Pen) in aqueous medium, were examined, The thiol quantification was carried out using Elman's method through UV-visible spectrophotometry and 1H- NMR. Results of the study performed in aqueous medium showed that level of different thiols depleted after the addition of the inorganic salts and organic complexes of Palladium. The mechanism of interaction of Palladium with thiols was examined using H-NMR. The results indicate that the depletion in the level of thiols may be due to 1:1 or 1:2 conjugation of Palladium with thiols. These conjugation reactions further suggest that the Palladium have xenobiotic nature causing oxidative stress and thiols play their role in detoxification and biotransformation of these metalloelements.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP7440053	Palladium		7440-05-3	Price

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