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Requirement of AMPK Activation for Neuronal Metabolic-Enhancing Effects of Antidepressant Paroxetine

Requirement of AMPK Activation for Neuronal Metabolic-Enhancing Effects of Antidepressant Paroxetine

Jihyeon Jeong, Minsun Park, Jeong Seon Yoon, Hyunjeong Kim, Su Kyoung Lee, Eun Lee, Kee Namkoong, Eosu Kim

Neuroreport. 2015 May 6;26(7):424-8.

PMID: 25839176

Abstract:

Reduced glucose metabolism has been implicated as a pathophysiology of depressive disorder. Normalization of such impaired neurometabolism has been related to the therapeutic actions of antidepressant medication. However, the molecular mechanism underlying the neurometabolic actions of antidepressants has not been fully understood. Given that AMP-activated protein kinase (AMPK) is a master switch for energy homeostasis, we aimed to determine whether selective serotonin reuptake inhibitor paroxetine enhances energy metabolism by activating AMPK in neuroblastoma cells. We found that paroxetine dose dependently increased mitochondrial biogenesis, which involves the AMPK-peroxisome proliferator-activated receptor-γ coactivator-1α pathway. In addition, paroxetine-induced AMPK activation increases glucose uptake and ATP production. These neurometabolic effects of paroxetine were suppressed by cotreatment with compound C (CC), an AMPK inhibitor. These findings suggest a possibility that modulation of the AMPK pathway might be a previously unrecognized mechanism underlying the neurometabolic action of antidepressants. Further study is warranted to examine the region-specific and time-specific effects of AMPK modulation by antidepressants on mood-related behaviors.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS31042715	Paroxetine Related Compound C			Price

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