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[Research Progress of Acute Kanamycin Sulfate-Induced Deafness in Guinea Pig]

Zedeng Yin, Weijia Kng

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2012 May;26(10):478-80.

PMID: 22870728

Abstract:

To present a summary of current knowledge regarding acute kanamycin sulfate-induced deafness in guinea pig, by reviewing the published literature. Animal model of acute deafness induced by a single dose of kanamycin sulfate in combination with ethacrynic acid or furosemide in guinea pig was usually used to investigate the mechanism of cochlear cell degeneration. There were different time sequences of cell degeneration of spiral ganglion cell and hair cell in different studies. The findings may result from different doses, order of two drugs administration or time point chosen. There remains scope for further research in chronic kanamycin-induced deafness, which more replicates the type of exposure to people than acute deafness.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP25389940-A Kanamycin Sulfate Kanamycin Sulfate 25389-94-0 Price
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