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Researches on Psychotropic Agents. IV. Synthesis and Neuropsychopharmacological Effects of 1,3,4,14 b-tetrahydro-10-methyl-2H,10H- pyrazino[2,1-d] pyrrolo[1,2-b][1,2,5]benzotriazepine and Its Derivatives

Researches on Psychotropic Agents. IV. Synthesis and Neuropsychopharmacological Effects of 1,3,4,14 b-tetrahydro-10-methyl-2H,10H- pyrazino[2,1-d] pyrrolo[1,2-b][1,2,5]benzotriazepine and Its Derivatives

G Stefancich, M Artico, R Silvestri, G C Pantaleoni, R Giorgi, G Palumbo

Farmaco. Jul-Aug 1992;47(7-8):987-99.

PMID: 1445618

Abstract:

The synthesis and neuropsychopharmacological properties of new 1,3,4,14b-tetrahydro-2H,10H-pyrazino [2,1-d] pyrrolo [1,2-b] [1,2,5] benzotriazepine derivatives related to antidepressant agent aptazepine are reported. The new derivatives displayed sedative-miorelaxant activity in mice, but no significant antagonist effect on clonidine blockade of phenylquinone-induced abdominal constriction. Among test compounds 4a, 4l and 4n showed high antinociceptive effect on the hot-plate test and compound 4e protected from death and convulsion all the electroshocked animals.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
CS31041177	Clonidine Related Compound B			Price

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