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Resistin-like Molecule-Beta Is an Allergen-Induced Cytokine With Inflammatory and Remodeling Activity in the Murine Lung

Resistin-like Molecule-Beta Is an Allergen-Induced Cytokine With Inflammatory and Remodeling Activity in the Murine Lung

Anil Mishra, Meiqin Wang, James Schlotman, Nikolaos M Nikolaidis, Charles W DeBrosse, Margaret L Karow, Marc E Rothenberg

Am J Physiol Lung Cell Mol Physiol. 2007 Aug;293(2):L305-13.

PMID: 17545488

Abstract:

Resistin-like molecule (RELM)-beta is a cysteine-rich cytokine implicated in insulin resistance and asthmatic responses, but its function remains an enigma. We now report that RELM-beta has a role in promoting airway inflammation and lung remodeling in the mouse lung. RELM-beta is strongly induced by diverse allergens and T helper type 2 (Th2) cytokines by an IL-13- and STAT6-dependent mechanism. To understand the in vivo role of RELM-beta, we delivered recombinant murine RELM-beta intratracheally to naïve mice. RELM-beta induced dose-dependent leukocyte accumulation (most prominently involving macrophages) and goblet cell hyperplasia. The most prominent effect induced by RELM-beta was increased perivascular and peribronchial collagen deposition. Mice genetically deficient in RELM-beta had reduced accumulation of collagen and goblet cell hyperplasia in an experimental model of allergic airway inflammation. In vitro experiments demonstrated that RELM-beta had fibroblast motogenic activity. These results identify RELM-beta as a Th2-associated cytokine with potent inflammatory and remodeling activity.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42413502	RELM-beta from mouse			Price

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