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Response of Captive Skunks to Microencapsulated Tetracycline

Response of Captive Skunks to Microencapsulated Tetracycline

Brandon S Schmit, Thomas M Primus, Jerome C Hurley, Dennis J Kohler, Shawna F Graves

J Wildl Dis. 2010 Jul;46(3):1024-8.

PMID: 20688717

Abstract:

A captive striped skunk (Mephitis mephitis) study was conducted between February and June 2004 at the United States Department of Agriculture, Animal and Plant Health Inspection Service, Wildlife Services National Wildlife Research Center, Fort Collins, Colorado, USA. The main objective was to determine the percentage of adult striped skunks that were marked after consuming placebo oral rabies vaccine (ORV) baits containing 100 mg of an experimental microencapsulated (coated microparticle) tetracycline hydrochloride biomarker. Biomarkers were identified in the canine teeth and mandibles of five of five skunks that consumed an ORV bait. A second objective was to determine if the microencapsulated tetracycline was resistant to photochemical conversion from tetracycline to epitetracycline. After 15 days of exposure, conversion from tetracycline to epitetracycline concentration in the microencapsulated product (mean 1.9% conversion, SD=1.24) was significantly less (P=0.006) than the pure-grade tetracycline powder (mean 7.5% conversion, SD=1.37). Results support the use of microencapsulated tetracycline hydrochloride as a biomarker in circumstances where the use of conventional powdered tetracycline hydrochloride is not feasible due to ORV bait design constraints.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP23313806-B	Epitetracycline hydrochloride		23313-80-6	Price

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